DRAVP ID  DRAVPe02005

Peptide Name   Peptide 7

Sequence  MVDRGWGNGCGLFGKGGI

Sequence Length  18

UniProt ID  No entry found

Source  Synthetic construct

Target Organism  DENV

Assay  Antiviral assays(Cell protection assay, Direct virus inhibition assay, Post-infection assay, Viral attachment assay, Viral entry assay)

Activity  [Ref.36739680]Peptides 7 at 200 μM exhibited good inhibitions of DENV-1 (67.17%) plaque formation, but much lower inhibitions were observed against DENV-2 to 4 ranging from 28.31 to 37.73%; peptide 7 (200 μM) showed good direct virus-inactivating effects against DENV-3 (64.03%) and DENV-4 (78.76%) whereas lower inhibitions were observed against DENV-1 (32.66%) and DENV-2 (47.84%); peptide 7 demonstrated highly significant inhibition of DENV-4 at 84.82% during post-infection, much lower inhibitions were observed against DENV-2 and 3 at 9.13% and 2.24%; Peptide 7 was observed to inhibit DENV-4 replications significantly with reductions of RNA copy numbers by 77.01%.

Hemolytic Activity  No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity 

• [Ref.36739680]did not exhibit any significant cytotoxic effects towards Vero cells up to 200 μM.

Binding Target  Not found

Mechanism  No machanism information found in the reference(s) presented in this entry

PDB ID  None

Predicted Structure Download  No predicted structure available

Linear/Cyclic  Linear

N-terminal Modification  Acetylation

C-terminal Modification  Amidation

Other Modification  None

Stereochemistry  L

Literature 1

Title   Development of novel antiviral peptides against dengue serotypes 1-4. 

Pubmed ID   36739680

Reference   Virology. 2023 Mar;580:10-27.

Author   Lee MF, Anasir MI, Poh CL. 

DOI   10.1016/j.virol.2023.01.016