To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.
General Information
DRAVP ID DRAVPe02010
Peptide Name Peptide 12
Sequence DANFV
Sequence Length 5
UniProt ID No entry found
Source Synthetic construct
Activity Information
Target Organism DENV
Assay Antiviral assays(Cell protection assay, Direct virus inhibition assay, Post-infection assay, Viral attachment assay, Viral entry assay)
Activity [Ref.36739680]Peptides 12 at 200 μM exhibited cell protection effects below 50% against all four DENV serotypes(DENV-1, DENV-2, DENV-3, DENV-4); peptide 12 (200 μM) also showed inhibitions of all four DENV serotypes, but significantly lower inhibitions were observed against DENV-3 at 2.28%.
Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry
Cytotoxicity
Binding Target Not found
Mechanism No machanism information found in the reference(s) presented in this entry
Structure Information
PDB ID None
Predicted Structure Download No predicted structure available
Linear/Cyclic Linear
N-terminal Modification Acetylation
C-terminal Modification Amidation
Other Modification None
Stereochemistry L
Physicochemical Information
Formula C25H36N6O9
Absent amino acids CEGHIKLMPQRSTWY
Common amino acids ADFNV
Mass 564.6
Pl 3.8
Basic residues 0
Acidic residues 1
Hydrophobic residues 3
Net charge -1
Boman Index -653
Hydrophobicity 36
Aliphatic Index 78
Half Life
Extinction Coefficient cystines 0
Absorbance 280nm 0
Polar residues 1
Literature Information
Literature 1
Title Development of novel antiviral peptides against dengue serotypes 1-4.
Pubmed ID 36739680
Reference Virology. 2023 Mar;580:10-27.
Author Lee MF, Anasir MI, Poh CL.
To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.