DRAVP ID  DRAVPe02011

Peptide Name   peptides 5F

Sequence  PFGDSYIVI

Sequence Length  9

UniProt ID  No entry found

Source  Synthetic construct

Target Organism  DENV

Assay  Antiviral assays(Cell protection assay, Direct virus inhibition assay, Post-infection assay, Viral attachment assay, Viral entry assay)

Activity  [Ref.36739680]At 100 μM, peptides 5F demonstrated some cell protection effects against DENV-1 (22.89%), DENV-2 (48.28%) and DENV-4(66.72%); Peptide 5F at 100 μM was observed to exhibit higher inhibition of DENV-4 at 66.72% during the pre-infection stage when compared to peptide 5 which only demonstrated 59.72% inhibition of DENV-4 at 200 μM; Peptides 5F(100 μM) also demonstrated direct virus-inactivating effects against DENV-1 at 46.75%, DENV-2(75.15%), DENV-3(10.81%), DENV-4(70.15%); Peptides 5F at 100 μM showed inhibitions against DENV-1 during the post-infection stage at 49.65%, DENV-2(47.49%), DENV-4(91.58%).

Hemolytic Activity  No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity 

• [Ref.36739680]did not exhibit any significant cytotoxic effects towards Vero cells up to 200 μM.(cell viability was found to range between 92.98 and 100% at 200 μM).

Binding Target  Not found

Mechanism  No machanism information found in the reference(s) presented in this entry

PDB ID  None

Predicted Structure Download  No predicted structure available

Linear/Cyclic  Linear

N-terminal Modification  Acetylation

C-terminal Modification  Amidation

Other Modification  None

Stereochemistry  L

Literature 1

Title   Development of novel antiviral peptides against dengue serotypes 1-4. 

Pubmed ID   36739680

Reference   Virology. 2023 Mar;580:10-27.

Author   Lee MF, Anasir MI, Poh CL. 

DOI   10.1016/j.virol.2023.01.016