DRAVP ID  DRAVPe02013

Peptide Name   peptides 5G

Sequence  LTLHWFRK

Sequence Length  8

UniProt ID  No entry found

Source  Synthetic construct

Target Organism  DENV

Assay  Antiviral assays(Cell protection assay, Direct virus inhibition assay, Post-infection assay, Viral attachment assay, Viral entry assay)

Activity  [Ref.36739680]At 100 μM, peptides 5G demonstrated some cell protection effects against DENV-1 (25.24%), DENV-4(26.80%), DENV-2 (49.24%) and DENV-3(41.08%); Peptide 5G (100 μM) demonstrated a slight increase in inhibition of DENV-3 at 41.08% during pre-infection whereas peptide 5 at 200 μM only showed 37.41% inhibition against DENV-3; Peptides 5G (100 μM) also demonstrated direct virus-inactivating effects against DENV-1 at 48.23%, DENV-2 (56.25%), DENV-3(29.91%), DENV-4(72.27%); Peptides 5G at 100 μM showed inhibitions against DENV-1 during the post-infection stage at 24.59%, DENV-4(71.95%)

Hemolytic Activity  No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity 

• [Ref.36739680]did not exhibit any significant cytotoxic effects towards Vero cells up to 200 μM.(cell viability was found to range between 92.98 and 100% at 200 μM).

Binding Target  Not found

Mechanism  No machanism information found in the reference(s) presented in this entry

PDB ID  None

Predicted Structure Download  No predicted structure available

Linear/Cyclic  Linear

N-terminal Modification  Acetylation

C-terminal Modification  Amidation

Other Modification  None

Stereochemistry  L

Literature 1

Title   Development of novel antiviral peptides against dengue serotypes 1-4. 

Pubmed ID   36739680

Reference   Virology. 2023 Mar;580:10-27.

Author   Lee MF, Anasir MI, Poh CL. 

DOI   10.1016/j.virol.2023.01.016