DRAVP ID  DRAVPe02015

Peptide Name   WL-1

Sequence  GWKRIKQRIKDKLRNL

Sequence Length  16

UniProt ID  No entry found

Taxon ID  None

Source  Synthetic construct

Validation   Experimentally Validated

Gene Name/ID  Not Available

GenBank  Not Available

Amino Acid position  Not Available

Domain Accession ID  Not Available

Nucleotide sequence ID  Not Available

Molecular Type  Not Available

Chromosomal Position  Not Available

Target Organism  HSV-1

Assay  Plaque-forming assay

Activity 

• [Ref.37342565]herpes simplex virus 1(HSV-1): WL-1 significantly inhibited the replication of HSV-1 on Vero cells(10 μM concentration with a 50% antiviral activity).

Hemolytic Activity  No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity 

• [Ref.37342565]WL-1 did not exert toxic effects on neuronal cell (U251) and epithelial cell (Vero) up to 50 μM concentration.

Binding Target  virus replication

Mechanism  WL-1 may damage the viral membrane envelope or inhibit HSV-1 adsorption to cells, or perhaps participates in the regulation of the viral replication cycle and inflammatory response caused by viral infection.

PDB ID  None

Predicted Structure Download  No predicted structure available

Linear/Cyclic  Linear

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Stereochemistry  L

Literature 1

Title   Cathelicidin-derived antiviral peptide inhibits herpes simplex virus 1 infection. 

Pubmed ID   37342565

Reference   Front Microbiol. 2023 Jun 5;14:1201505.

Author   Guo X, An Y, Tan W, Ma L, Wang M, Li J, Li B, Hou W, Wu L.

DOI   10.3389/fmicb.2023.1201505.