General Information

General Information

DRAVP ID DRAVPe02015

Peptide Name WL-1

Sequence GWKRIKQRIKDKLRNL

Sequence Length 16

UniProt ID No entry found

Source Synthetic construct

Activity Information

Target Organism HSV-1

Assay Plaque-forming assay

Activity

[Ref.37342565]herpes simplex virus 1(HSV-1): WL-1 significantly inhibited the replication of HSV-1 on Vero cells(10 μM concentration with a 50% antiviral activity).

Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity

[Ref.37342565]WL-1 did not exert toxic effects on neuronal cell (U251) and epithelial cell (Vero) up to 50 μM concentration.

Binding Target virus replication

Mechanism WL-1 may damage the viral membrane envelope or inhibit HSV-1 adsorption to cells, or perhaps participates in the regulation of the viral replication cycle and inflammatory response caused by viral infection.

Structure Information

PDB ID None

Predicted Structure Download No predicted structure available

Linear/Cyclic Linear

N-terminal Modification Free

C-terminal Modification Free

Other Modification None

Stereochemistry L

Physicochemical Information

Formula C92H162N32O21

Absent amino acids ACEFHMPSTVY

Common amino acids K

Mass 2052.5

Pl 11.74

Basic residues 7

Acidic residues 1

Hydrophobic residues 5

Net charge 6

Boman Index -6491

Hydrophobicity -151.88

Aliphatic Index 97.5

Half Life

Mammalian:30 hour
Yeast:>20 hour
E.coli:>10 hour

Extinction Coefficient cystines 5500

Absorbance 280nm 366.67

Polar residues 2

Literature Information

Literature 1

Title Cathelicidin-derived antiviral peptide inhibits herpes simplex virus 1 infection.

Pubmed ID 37342565

Reference Front Microbiol. 2023 Jun 5;14:1201505.

Author Guo X, An Y, Tan W, Ma L, Wang M, Li J, Li B, Hou W, Wu L.

DOI 10.3389/fmicb.2023.1201505.