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General Information
DRAVP ID DRAVPe02020
Peptide Name Urumin
Sequence IPLRGAFINGRWDSQCHRFSNGAIACA
Sequence Length 27
UniProt ID P0DTB9
Taxon ID 1690667
Source Skin of the South Indian frog(Hydrophylax bahuvistara)
Other Link DRAVPa0001
Validation Experimentally Validated
Origin Information
Gene Name/ID Not Available
GenBank Not Available
Amino Acid position 1 to 27
Domain Accession ID P0DTB9.1
Nucleotide sequence ID Not Available
Molecular Type Not Available
Chromosomal Position Not Available
Activity Information
Target Organism H1N1
Assay Not Available
Activity
Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry
Cytotoxicity
Binding Target Stalk region of H1
Mechanism Amphibian peptide that shows viricidal activity against human H1N1 influenza A virus. It specifically targets the conserved stalk region of H1 hemagglutinin, and acts by actively destroying influenza virions. It shows a reduced activity on human H3N2 influenza A virus and no activity against other viruses (HIV, SIV, HSV-II, hepatitis C, Ebola, Zika, and Dengue viruses). In vivo, the peptide also protects mice infected with mouse-adapted influenza virus from lethal influenza infection. The peptide synthesized in D-amino acids is inactive.
Structure Information
PDB ID None
Predicted Structure Download No predicted structure available
Linear/Cyclic Linear
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Stereochemistry L
Physicochemical Information
Formula C129H201N40O35S2
Absent amino acids EKMTYVOU
Common amino acids A
Mass 2961.39
Pl 9.02
Basic residues 3
Acidic residues 1
Hydrophobic residues 10
Net charge 2
Boman Index 1.2512
Hydrophobicity -0.033
Aliphatic Index 72.59
Half Life
Extinction Coefficient cystines 5500
Absorbance 280nm 1.857
Polar residues 14
Literature Information
Literature 1
Title An Amphibian Host Defense Peptide Is Virucidal for Human H1 Hemagglutinin-Bearing Influenza Viruses
Pubmed ID 28423338
Reference Immunity, 46(4), 587–595
Author Holthausen, D. J., Lee, S. H., Kumar, V. T., Bouvier, N. M., Krammer, F., Ellebedy, A. H., Wrammert, J., Lowen, A. C., George, S., Pillai, M. R., & Jacob, J. (2017)
To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.