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General Information
DRAVP ID DRAVPe02070
Peptide Name BmKn2
Sequence FIGAIARLLSKIF
Sequence Length 13
UniProt ID None
Taxon ID 34649
Source venom, Buthus martensii Karsch
Validation Experimentally Validated
Origin Information
Gene Name/ID Not Available
GenBank Not Available
Amino Acid position Not Available
Domain Accession ID Not Available
Nucleotide sequence ID Not Available
Molecular Type Not Available
Chromosomal Position Not Available
Activity Information
Target Organism HIV-1
Assay Antiviral effect assay
Activity
Hemolytic Activity
Cytotoxicity No cytotoxicity information found in the reference(s) presented
Binding Target Not Found
Mechanism BmKn2 aggregates and inserts into viral envelope so that the hydrophobic peptide region aligns with the lipid core region and the hydrophilic peptide regions form the interior region of the pore, with the help of positive charge of peptide somehow
Structure Information
PDB ID None
Predicted Structure Download No predicted structure available
Linear/Cyclic Linear
N-terminal Modification Free
C-terminal Modification Free
Other Modification While deletions of 1 to 4 residues from the peptide (Kn2-1 to Kn2-6) reduced its activity against S. aureus, peptide Kn2-7 (changes of G3, A4, and S10 to cationic K/R) showed increased activity due to an increase in cationicity. However, C-terminally truncated or cyclic BmKn2 lost activity against N. gonorrhoeae, indicating both the linear and intact sequence are important for peptide activity.
Stereochemistry L
Physicochemical Information
Formula C71H117N17O15
Absent amino acids NDCQEHMPTWYVOU
Common amino acids I
Mass 1448.81
Pl 11
Basic residues 3
Acidic residues 0
Hydrophobic residues 10
Net charge 3
Boman Index -0.86
Hydrophobicity 1.592
Aliphatic Index 165.38
Half Life
Extinction Coefficient cystines 0
Absorbance 280nm 0
Polar residues 13
Literature Information
Literature 1
Title Anti-HIV-1 activity of a new scorpion venom peptide derivative Kn2-7
Pubmed ID 22536342
Reference PloS one, 7(4), e34947.
Author Chen, Y., Cao, L., Zhong, M., Zhang, Y., Han, C., Li, Q., Yang, J., Zhou, D., Shi, W., He, B., Liu, F., Yu, J., Sun, Y., Cao, Y., Li, Y., Li, W., Guo, D., Cao, Z., & Yan, H. (2012).
To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.