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General Information
DRAVP ID DRAVPe02072
Peptide Name Brevinin-1
Sequence FLPVLAGIAAKVVPALFCKITKKC
Sequence Length 24
UniProt ID P32423
Taxon ID 88447
Source Frog, Rana brevipoda porsa, Japan, Asia
Validation Experimentally Validated
Origin Information
Gene Name/ID Not Found
GenBank Not Available
Amino Acid position 1to24
Domain Accession ID Not Available
Nucleotide sequence ID Not Available
Molecular Type Not Available
Chromosomal Position Not Available
Activity Information
Target Organism HSV-1,HSV-2
Assay Inhibition assay
Activity
Hemolytic Activity
Cytotoxicity
Binding Target Cell Membrane
Mechanism Brevinin-1 has demonstrated antiviral activity against herpes simplex virus (HSV), primarily by targeting the viral envelope and interfering with viral entry
Structure Information
PDB ID None
Predicted Structure Download No predicted structure available
Linear/Cyclic Linear
N-terminal Modification Free
C-terminal Modification Free
Other Modification Brevinin-1 was reduced and alkylated
Stereochemistry L
Physicochemical Information
Formula C121H204N28O26S2
Absent amino acids RNDQEQMSWYOU
Common amino acids AK
Mass 2527.5
Pl 99.7
Basic residues 4
Acidic residues 0
Hydrophobic residues 14
Net charge 4
Boman Index -1.19
Hydrophobicity 1.288
Aliphatic Index 134.17
Half Life
Extinction Coefficient cystines 0
Absorbance 280nm 0
Polar residues 20
Literature Information
Literature 1
Title Evaluation of the inactivation of infectious Herpes simplex virus by host-defense peptides
Pubmed ID 10795591
Reference European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, 19(3), 187–194.
Author Yasin, B., Pang, M., Turner, J. S., Cho, Y., Dinh, N. N., Waring, A. J., Lehrer, R. I., & Wagar, E. A. (2000)
To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.