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General Information
DRAVP ID DRAVPe02130
Peptide Name Mollamide E
Sequence XFPSLTCLSTXC
Sequence Length 10
UniProt ID None
Taxon ID None
Source Tunicate Didemnum molle PNG07-2-050
Validation Experimentally Validated
Origin Information
Gene Name/ID Not Available
GenBank Not Available
Amino Acid position Not Available
Domain Accession ID Not Available
Nucleotide sequence ID Not Available
Molecular Type Not Available
Chromosomal Position Not Available
Activity Information
Target Organism HIV-1
Assay HIV integrase inhibition assay and cytoprotective cell-based assay
Activity
Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry
Cytotoxicity No cytotoxicity information found in the reference(s) presented
Binding Target Viral integrase
Mechanism Mollamide E does not exhibit significant HIV inhibition activity in cytoprotective or integrase assays. Its mechanism of action remains uncharacterized but may involve steric or structural features that prevent integrase binding, unlike its analog Mollamide F
Structure Information
PDB ID None
Predicted Structure Download No predicted structure available
Linear/Cyclic Cyclic
N-terminal Modification Phenylalanine (Phe)
C-terminal Modification Thiazoline (Cys-derived residue)
Other Modification The cysteine residue forms a thiazoline ring, contributing to the rigidity and cyclic nature of the peptide.Attached to the threonine residue, this modification is a unique structural feature.Contains d-Phe and d-thiazoline, resulting from thermodynamic relaxation under constrained peptide geometry.X at position 1: D-Phenylalanine (D-Phe) → Mirror image of L-Phe, not commonly found in natural peptides, X at position 7: D-Cysteine in thiazoline ring → Modified residue, involved in heterocyclic st
Stereochemistry L
Physicochemical Information
Formula C35H50N6O7S
Absent amino acids ARNDQEGHIKMWYVOU
Common amino acids CLST
Mass 1071.27
Pl 5.51
Basic residues 0
Acidic residues 0
Hydrophobic residues 8
Net charge 0
Boman Index 0.96
Hydrophobicity 1.08
Aliphatic Index 78
Half Life
Extinction Coefficient cystines 0
Absorbance 280nm 0
Polar residues 8
Literature Information
Literature 1
Title Thiazoline Peptides and a Tris-Phenethyl Urea from Didemnum molle with Anti-HIV Activity
Pubmed ID 22845329
Reference J Nat Prod. 2012 Aug 24;75(8):1436-40.
Author Lu Z, Harper MK, Pond CD, Barrows LR, Ireland CM, Van Wagoner RM.
To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.