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General Information
DRAVP ID DRAVPe02131
Peptide Name Mollamide F
Sequence XFPPVIXC
Sequence Length 6
UniProt ID None
Taxon ID None
Source Tunicate Didemnum molle PNG07-2-050
Validation Experimentally Validated
Origin Information
Gene Name/ID Not Available
GenBank Not Available
Amino Acid position Not Available
Domain Accession ID Not Available
Nucleotide sequence ID Not Available
Molecular Type Not Available
Chromosomal Position Not Available
Activity Information
Target Organism HIV-1
Assay HIV integrase inhibition assay and cytoprotective cell-based assay
Activity
Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry
Cytotoxicity No cytotoxicity information found in the reference(s) presented
Binding Target Viral integrase
Mechanism Mollamide F inhibits HIV-1 integrase with an IC50 value of 39 µM, suggesting it interacts with integrase's active site. Residues in the "southern region" of the peptide are crucial for binding. The thiazoline moiety likely contributes to molecular rigidity and facilitates integrase interaction.
Structure Information
PDB ID None
Predicted Structure Download No predicted structure available
Linear/Cyclic Cyclic
N-terminal Modification Phenylalanine (Phe)
C-terminal Modification Thiazoline (Cys-derived residue)
Other Modification Similar to Mollamide E, it contains a thiazoline ring derived from cysteine.The sequence includes two proline residues, with a cis geometry at the Pro-Pro peptide bond.Contains d-Phe and d-thiazoline, similar to Mollamide E, due to stereochemical lability. Unlike Mollamide E, the reversed isoprene group is missing, which impacts its structural dynamics and activity.X at position 1: D-Phenylalanine (D-Phe) → This is a D-isomer, which is not naturally common in ribosomally synthesized peptides.X a
Stereochemistry L
Physicochemical Information
Formula C33H46N6O5S
Absent amino acids ARNDQEGHLKMSTWTOU
Common amino acids P
Mass 674.86
Pl 5.52
Basic residues 0
Acidic residues 0
Hydrophobic residues 6
Net charge 0
Boman Index 0.88
Hydrophobicity 1.8
Aliphatic Index 113.33
Half Life
Extinction Coefficient cystines 0
Absorbance 280nm 0
Polar residues 6
Literature Information
Literature 1
Title Thiazoline Peptides and a Tris-Phenethyl Urea from Didemnum molle with Anti-HIV Activity
Pubmed ID 22845329
Reference J Nat Prod. 2012 Aug 24;75(8):1436-40.
Author Lu Z, Harper MK, Pond CD, Barrows LR, Ireland CM, Van Wagoner RM.
To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.