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General Information
DRAVP ID DRAVPe02135
Peptide Name Divamide A
Sequence ECASTCSFGIVTIVCDGTTK
Sequence Length 20
UniProt ID A0A2H4GZ80
Taxon ID 1216
Source TunicateDidemnum molle E11-036
Validation Experimentally Validated
Origin Information
Gene Name/ID divA
GenBank ARD09202.1
Amino Acid position 72-91
Domain Accession ID Not Available
Nucleotide sequence ID KY115608
Molecular Type Genomic DNA
Chromosomal Position Not Available
Activity Information
Target Organism HIV-1
Assay HIV assay
Activity
Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry
Cytotoxicity
Binding Target PE binding
Mechanism duramycin inhibits entry of Ebola and Dengue viruses, indicating that TIM proteins also interact with PE.Thus, lipid binding appears a likely mechanism for the anti-HIV activity of the divamides. However, the stark differences in potency and toxicity between individual divamides and 4 may reflect additional interactions with non-membrane components, potentially including TIM proteins, that are substantially affected by the peptide sequence.
Structure Information
PDB ID None
Predicted Structure Download No predicted structure available
Linear/Cyclic Cyclic
N-terminal Modification Free
C-terminal Modification Free
Other Modification the tertiary structure conferred by the cyclic lysinoalanine residue is necessary to block infection
Stereochemistry L
Physicochemical Information
Formula C84H139N21O31S3
Absent amino acids RNQHMWYOU
Common amino acids T
Mass 2035.33
Pl 4.37
Basic residues 1
Acidic residues 2
Hydrophobic residues 14
Net charge -1
Boman Index 0.9576
Hydrophobicity 0.671
Aliphatic Index 73
Half Life
Extinction Coefficient cystines 0
Absorbance 280nm 0
Polar residues 16
Literature Information
Literature 1
Title Accessing chemical diversity from the uncultivated symbionts of small marine animals
Pubmed ID 29291350
Reference Nat Chem Biol. 2018 Feb;14(2):179-185.
Author Smith TE, Pond CD, Pierce E, Harmer ZP, Kwan J, Zachariah MM, Harper MK, Wyche TP, Matainaho TK, Bugni TS, Barrows LR, Ireland CM, Schmidt EW.
To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.