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DRAVP ID DRAVPa1405
Peptide Name Sequence 16 from Patent US 20040091855
Sequence TLTVQARQLLSGIVQQQNNLLRAIEAQQHLLQLTVW
Sequence Length 36
Source Synthetic construct
Target Organism HIV
Patent Type Patent Application
Publication Date 2004-05-13
Patent No US 2004/0091855 A1
Family Info US 2004/0091855 A1
Patent Title Method for production of antivirals by use of HIV-derived HR1 peptides, and trimers formed therefrom
Comment No comments found in patent
Abstract Provided is a method for identifying or producing a molecule having antiviral activity against HIV. More particularly, provided is a method for identifying or producing a molecule that can inhibit the binding between HR1 and HR2 regions of HIV gp41, wherein complex formation is observed in vitro between a trimer with HR2 peptide in the presence of the molecule, and detected in vitro is the ability of the molecule to inhibit complex formation as an indicator of the antiviral activity of the molecule. The trimer is comprised of synthetic peptide comprising an amino acid sequence derived from the HR1 region of HIV-1 gp41 and further comprising one or more amino acid substitutions in a hydrophobic domain of the HR1 region of HIV which enable the synthetic peptide to self-assemble in solution into trimers.
To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.