DRAVP ID  DRAVPa1462

Peptide Name   Sequence 30 from Patent US 20050130884

Sequence  RRKKAAVA

Sequence Length  8

Source  Synthetic construct

Target Organism  HSV

Patent Type  Patent Application

Publication Date  2005-06-16

Patent No  US 2005/0130884 A1

Family Info  WO 2001/057072 A2, CA 2399676 A1, AU 2001/036700 A, WO 2001/057072 A3, EP 1272510 A2, JP 2003522185 A, US 2005/0130884 A1, AU 784264 B2, EP 1272510 B1, AT 374208 T, DE 60130641 D1, ES 2293977 T3, US 7

Patent Title  Pharmacologically active antiviral peptides and methods of their use

Comment  The peptide shows antiviral activity against a wide range of enveloped and non-enveloped viruses. Examples of such enveloped viruses include, but are not limited to, human immunodeficiency virus (HIV), vesiculovirus (VSV), herpes simplex viruses (HSV-1 and HSV-2), and other herpes viruses, for example, varicella-zoster virus (VZV), EBV, equine herpes virus (EHV), and human cytomegalovirus (HCMV). Examples of non-enveloped viruses include, but are not limited to, human papilloma virus (HPV) and adenoviruses.

Abstract  This invention relates to peptides having antiviral properties. The antiviral peptides comprise membrane transiting peptides, and active fragments and derivatives of such peptides. The antiviral peptides exhibit activity against a broad spectrum of viruses, including enveloped and nonenveloped viruses, and are used in pharmaceutical compositions to prevent and/or treat viral infections.