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DRAVP ID DRAVPa2210
Peptide Name AP30
Sequence WKHWYK
Sequence Length 6
Source Synthetic peptide
Target Organism GAstV
Patent Type Patent Application
Publication Date 2023-04-04
Patent No CN115894614A
Patent Title Antiviral affinity peptide of targeted goose astrovirus Spike protein and application of antiviral affinity peptide
Comment
Abstract The invention relates to an antiviral affinity peptide of a targeted goose astrovirus Spike protein and application of the antiviral affinity peptide. The sequence of the affinity peptide is WRCKVR, WKHKRR or WKHWYK. According to the method, a molecular docking virtual screening technology is adopted, a crystal structure of TAstV-4Spike protein is taken as a template, and SWISS-MODEL software is used for homologous modeling, so that a three-dimensional structure of the GAstV Spike protein is obtained. The method comprises the following steps: selecting a C-terminal partial region of a Spike protein structure as an active pocket by using SYBYL software, carrying out molecular docking on polypeptide ligands in a library and the selected pocket by using a Surflex-Dock/SYBYL function, comprehensively evaluating a docking result according to Cscore, screening out the affinity peptide for specifically identifying the GAstV Spike protein, and laying a foundation for subsequent research on antiviral polypeptide drugs
To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.