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DRAVP ID DRAVPa2303
Peptide Name Sequence 5 from Patent US6337074B1
Sequence VFTGVLAGVWGEGGKFVYPFDDKMSFLFA
Sequence Length 29
Source Synthetic peptide
Target Organism Herpesviruses
Patent Type Granted Patent
Publication Date 2002-01-08
Patent No US6337074B1
Family Info EP0918866, AU1997037013, WO/1998/004707, US20050164163
Patent Title Anti-herpesviral agent
Comment
Abstract An antiviral agent capable of disrupting the association of two viral proteins required for DNA replication in herpesviruses. The agents disrupt the association of UL8 and POL in HSV-1 or the association of equivalent homologues of these proteins in other herpesviruses (for example UL 102 and UL54 in HCMV). Suitable agents are peptides which mimic the C-terminal or C-proximal portion of UL8 (or its homologues) for example the peptide IELVFTGVLAGVWGEGGKFV. Peptidomimetic compounds of such peptides are also suitable anti-viral agents. An assay to test for agents capable of disrupting association of POL and UL12 (or homologues thereof) is also described.
To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.