DRAVPR ID  DRAVPR0001

Name   Phospholipid scramblase 1(PL scramblase 1,PLSCR1)

Sequence  MDKQNSQMNASHPETNLPVGYPPQYPPTAFQGPPGYSGYPGPQVSYPPPPAGHSGPGPAGFPVPNQPVYNQPVYNQPVGAAGVPWMPAPQPPLNCPPGLEYLSQIDQILIHQQIELLEVLTGFETNNKYEIKNSFGQRVYFAAEDTDCCTRNCCGPSRPFTLRIIDNMGQEVITLERPLRCSSCCCPCCLQEIEIQAPPGVPIGYVIQTWHPCLPKFTIQNEKREDVLKISGPCVVCSCCGDVDFEIKSLDEQCVVGKISKHWTGILREAFTDADNFGIQFPLDLDVKMKAVMIGACFLIDFMFFESTGSQEQKSGVW

Sequence Length  318

Source  Homo sapiens (Human)

UniProt ID O15162

Gene PLSCR1

Target Organism  HBV,HIV-1,HTLV1,IAV,EBV,HCMV,HCV,VSV

Activity 

• [Ref.35650588]Hepatitis B virus(HBV):PLSCR1 plays an antiviral role by promoting the ubiquitination and proteasomal degradation of the HBV X protein (HBx), resulting in reduced HBx levels.
• Human immunodeficiency virus type-1(HIV-1):PLSCR1 exhibits antiviral activity by inhibiting Tat functions by reducing its nuclear localization and perturbing the virus entry process by modulating CD4-SLPI interaction.
• Human T-lymphotropic virus type 1 (HTLV-1):PLSCR1-Tax interaction reduced the cytoplasmic redistribution of Tax and its homodimerization, thus inhibiting Tax-mediated transactivation of HTLV-1 long terminal repeat.
• Influenza A virus (IAV):PLSCR1 inhibits the nuclear import of NP/vRNP thus limiting viral replication.
• Epstein-Barr virus (EBV): PLSCR1 represses BZLF1-dependent lytic gene expression.
• Human cytomegalovirus (HCMV):PLSCR1 inhibits CREB functions and CREB-IE2, CBP-IE2 complexes, resulting in the repression of HCMV replication.
• [Ref.15308695]Vesicular stomatitis virus (VSV):PLSCR1 inhibits accumulation of primary VSV transcripts, similar to the effects of IFN against VSV.
• [Ref.21806988]Hepatitis C virus (HCV):PLSCR1 contributes to HCV entry and infection through HCVpp and HCVcc assays.

PDB ID  1Y2A 

Predicted Structure Download  AF-O15162-F1

Modification  ①Phosphorylation of Tyr at position 69,74,161②The Cys at position 184,185,186,188 and 189 indicates S-palmitoyl cysteine.

PLSCR1 may play a role in the antiviral response of interferon (IFN) by amplifying and enhancing the IFN response through increased expression of select subset of potent antiviral genes.

Literature 1

Title   Phospholipid scramblase 1 potentiates the antiviral activity of interferon. 

Pubmed ID   15308695

Author   Dong B, Zhou Q, Zhao J, Zhou A, Harty RN, Bose S, Banerjee A, Slee R, Guenther J, Williams BR, Wiedmer T, Sims PJ, Silverman RH. 

Literature 2

Title   Phospholipid scramblase 1 mediates hepatitis C virus entry into host cells.

Pubmed ID   21806988

Author   Gong Q, Cheng M, Chen H, Liu X, Si Y, Yang Y, Yuan Y, Jin C, Yang W, He F, Wang J.

Literature 3

Title   Phospholipid scramblase 1: a protein with multiple functions via multiple molecular interactors.

Pubmed ID   35650588

Author   Dal Col J, Lamberti MJ, Nigro A, Casolaro V, Fratta E, Steffan A, Montico B.