To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.
General Information
DRAVPR ID DRAVPR0002
Name Cholesterol 25-hydroxylase(h25OH)
Sequence
Sequence Length 272
Source Homo sapiens (Human)
UniProt ID O95992
Gene CH25H
Activity Information
Target Organism SARS-CoV-2,VSV
Activity
Structure Information
PDB ID None
Predicted Structure Download AF-O95992-F1
Modification Glycosylation of Asn at position 5,163,189.
Comment
25HC has been shown to have broad antiviral activity by inhibiting the host cell entry of human immunodeficiency virus (HIV), vesicular stomatitis virus (VSV), Zika virus (ZIKV), Ebola virus (EBOV), Nipah virus (NiV), Russian spring-summer encephalitis virus (RSSEV), porcine viruses (PEDV, PEGV, porcine intestine coronavirus), reovirus, and norovirus. For ZIKV, treatment with 25HC protected mice and rhesus monkeys from ZIKV infection.
Literature Information
Literature 1
Title Cholesterol 25-hydroxylase suppresses SARS-CoV-2 replication by blocking membrane fusion.
Pubmed ID 33239446
Author Zang R, Case JB, Yutuc E, Ma X, Shen S, Gomez Castro MF, Liu Z, Zeng Q, Zhao H, Son J, Rothlauf PW, Kreutzberger AJB, Hou G, Zhang H, Bose S, Wang X, Vahey MD, Mani K, Griffiths WJ, Kirchhausen T, Fremont DH, Guo H, Diwan A, Wang Y, Diamond MS, Whelan SPJ, Ding S.
Literature 2
Title Cholesterol 25-Hydroxylase inhibits SARS-CoV-2 and other coronaviruses by depleting membrane cholesterol.
Pubmed ID 32944968
Author Wang S, Li W, Hui H, Tiwari SK, Zhang Q, Croker BA, Rawlings S, Smith D, Carlin AF, Rana TM.
To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.