General Information


DRAVPR ID  DRAVPR0004

Name   2'-5'-oligoadenylate synthase 1A

Sequence 

Sequence Length  367

Source  Mus musculus (Mouse)

UniProt ID P11928

Gene Oas1a



Activity Information


Target Organism  SARS-CoV-2

Activity 

  • [Ref.34581622]SARS-CoV-2:OAS1 recognizes short stretches of double-stranded RNA (dsRNA) and activates RNase L, which leads to degradation of cellular as well as viral RNA, resulting in the inhibition of protein synthesis, thus terminating viral replication.



Structure Information


PDB ID  None

Predicted Structure Download  AF-P11928-F1

';

Modification  The Cys at position 364 indicates S-geranylgeranyl cysteine.



Comment


Activation of RNase L leads to degradation of cellular as well as viral RNA, resulting in the inhibition of protein synthesis, thus terminating viral replication. Can mediate the antiviral effect via the classical RNase L-dependent pathway or an alternative antiviral pathway independent of RNase L.



Literature Information


Literature 1

Title   A prenylated dsRNA sensor protects against severe COVID-19. 

Pubmed ID   34581622

Author   Wickenhagen A, Sugrue E, Lytras S, Kuchi S, Noerenberg M, Turnbull ML, Loney C, Herder V, Allan J, Jarmson I, Cameron-Ruiz N, Varjak M, Pinto RM, Lee JY, Iselin L, Palmalux N, Stewart DG, Swingler S, Greenwood EJD, Crozier TWM, Gu Q, Davies EL, Clohisey S, Wang B, Trindade Maranhão Costa F, Freire Santana M, de Lima Ferreira LC, Murphy L, Fawkes A, Meynert A, Grimes G; ISARIC4C Investigators, Da Silva Filho JL, Marti M, Hughes J, Stanton RJ, Wang ECY, Ho A, Davis I, Jarrett RF, Castello A, Robertson DL, Semple MG, Openshaw PJM, Palmarini M, Lehner PJ, Baillie JK, Rihn SJ, Wilson SJ.