General Information


DRAVPR ID  DRAVPR0006

Name   MHC class II transactivator

Sequence 

Sequence Length  1130

Source  Homo sapiens (Human)

UniProt ID P33076

Gene CIITA



Activity Information


Target Organism  EBOV,SARS-CoV-2

Activity 

  • [Ref.32855215]Ebola virus (EBOV):The p41 isoform of CD74 disrupts cathepsin-mediated Ebola glycoprotein processing, which prevents viral fusion and entry.
  • SARS-CoV-2: CD74 p41 can stymie the endosomal entry of coronaviruses including SARS-CoV-2.



Structure Information


PDB ID  None

Predicted Structure Download  AF-P33076-F1

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Modification  No modifications on the sequence.



Comment


Has antiviral activity against Ebola virus and coronaviruses, including SARS-CoV-2. Induces resistance by up-regulation of the p41 isoform of CD74, which blocks cathepsin-mediated cleavage of viral glycoproteins, thereby preventing viral fusion



Literature Information


Literature 1

Title   MHC class II transactivator CIITA induces cell resistance to Ebola virus and SARS-like coronaviruses.

Pubmed ID   32855215

Author   Bruchez A, Sha K, Johnson J, Chen L, Stefani C, McConnell H, Gaucherand L, Prins R, Matreyek KA, Hume AJ, Mühlberger E, Schmidt EV, Olinger GG, Stuart LM, Lacy-Hulbert A.