To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.
General Information
DRAVPR ID DRAVPR0006
Name MHC class II transactivator
Sequence
Sequence Length 1130
Source Homo sapiens (Human)
UniProt ID P33076
Gene CIITA
Activity Information
Target Organism EBOV,SARS-CoV-2
Activity
Structure Information
PDB ID None
Predicted Structure Download AF-P33076-F1
Modification No modifications on the sequence.
Comment
Has antiviral activity against Ebola virus and coronaviruses, including SARS-CoV-2. Induces resistance by up-regulation of the p41 isoform of CD74, which blocks cathepsin-mediated cleavage of viral glycoproteins, thereby preventing viral fusion
Literature Information
Literature 1
Title MHC class II transactivator CIITA induces cell resistance to Ebola virus and SARS-like coronaviruses.
Pubmed ID 32855215
Author Bruchez A, Sha K, Johnson J, Chen L, Stefani C, McConnell H, Gaucherand L, Prins R, Matreyek KA, Hume AJ, Mühlberger E, Schmidt EV, Olinger GG, Stuart LM, Lacy-Hulbert A.
To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.