DRAVPR ID  DRAVPR0012

Name   Interferon-stimulated gene 20 kDa protein(ISG20)

Sequence  MAGSREVVAMDCEMVGLGPHRESGLARCSLVNVHGAVLYDKFIRPEGEITDYRTRVSGVTPQHMVGATPFAVARLEILQLLKGKLVVGHDLKHDFQALKEDMSGYTIYDTSTDRLLWREAKLDHCRRVSLRVLSERLLHKSIQNSLLGHSSVEDARATMELYQISQRIRARRGLPRLAVSD

Sequence Length  181

Source  Homo sapiens (Human)

UniProt ID Q96AZ6

Gene ISG20

Target Organism  HCV,HAV,YFV

Activity 

• [Ref.21036379]Hepatitis C virus (HCV):ISG20 inhibits HCV RNA replication and progeny virus release in Huh7.5 cells that lack both RIG-I and TLR3 viral RNA sensing pathways which recognize HCV replication and trigger IFN antiviral responses.
• ISG20 against HCV, HAV(hepatitis A virus), BVDV(bovine viral diarrhea virus) and YFV(yellow fever virus) all require the exonuclease activity of ISG20.

PDB ID  1WLJ 

Predicted Structure Download  AF-Q96AZ6-F1

Modification  No modifications on the sequence.

ISG20 is an interferon-inducible 3′–5′ exonuclease that inhibits replication of several human and animal RNA viruses.

Literature 1

Title   Antiviral activities of ISG20 in positive-strand RNA virus infections.

Pubmed ID   21036379

Author   Zhou Z, Wang N, Woodson SE, Dong Q, Wang J, Liang Y, Rijnbrand R, Wei L, Nichols JE, Guo JT, Holbrook MR, Lemon SM, Li K.

Literature 2

Title   ISG20, a new interferon-induced RNase specific for single-stranded RNA, defines an alternative antiviral pathway against RNA genomic viruses.

Pubmed ID   12594219

Author   Espert L, Degols G, Gongora C, Blondel D, Williams BR, Silverman RH, Mechti N.