General Information


DRAVPR ID  DRAVPR0027

Name   DNA dC->dU-editing enzyme APOBEC-3A

Sequence 

Sequence Length  199

Source  Homo sapiens (Human)

UniProt ID P31941

Gene APOBEC3A



Activity Information


Target Organism  HTLV-1,AAV

Activity 

  • [Ref.22457529]Human T-lymphotropic virus type 1(HTLV-1):APOBEC3A hapII potently decrease HTLV-1 infectivity.
  • [Ref.16527742]adeno-associated virus(AAV):APOBEC3A is a potent inhibitor of adeno-associated virus and retrotransposons.



Structure Information


PDB ID  2M65  4XXO  5KEG  5SWW  7D3V  7D3W  7D3X 

Predicted Structure Download  AF-P31941-F1

';

Modification  No modifications on the sequence.



Comment


Exhibits antiviral activity against adeno-associated virus (AAV) and human T-cell leukemia virus type 1 (HTLV-1) and may inhibit the mobility of LTR and non-LTR retrotransposons.



Literature Information


Literature 1

Title   APOBEC3A, APOBEC3B, and APOBEC3H haplotype 2 restrict human T-lymphotropic virus type 1.

Pubmed ID   22457529

Author   Ooms M, Krikoni A, Kress AK, Simon V, Münk C.

Literature 2

Title   APOBEC3A is a potent inhibitor of adeno-associated virus and retrotransposons.

Pubmed ID   16527742

Author   Chen H, Lilley CE, Yu Q, Lee DV, Chou J, Narvaiza I, Landau NR, Weitzman MD.