DRAVPR ID  DRAVPR0033

Name   DNA dC->dU-editing enzyme APOBEC-3G

Sequence  MKPHFRNPVERMYQDTFSDNFYNRPILSHRNTVWLCYEVKTKGPSRPPLDAKIFRGQVYSKLKYHPEMRFFHWFSKWRKLHRDQEYEVTWYISWSPCTKCTRDVATFLAEDPKVTLTIFVARLYYFWDPDYQEALRSLCQKRDGPRATMKIMNYDEFQHCWSKFVYSQRELFEPWNNLPKYYILLHIMLGEILRHSMDPPTFTSNFNNELWVRGRHETYLCYEVERLHNDTWVLLNQRRGFLCNQAPHKHGFLEGRHAELCFLDVIPFWKLDLHQDYRVTCFTSWSPCFSCAQEMAKFISNNKHVSLCIFAARIYDDQGRCQEGLRTLAKAGAKISIMTYSEFKHCWDTFVDHQGCPFQPWDGLEEHSQALSGRLRAILQNQGN

Sequence Length  384

Source  Pan troglodytes (Chimpanzee)

UniProt ID Q7YR24

Gene APOBEC3G

Target Organism  HIV-1,SFV

Activity 

• [Ref.12859895]Human immunodeficiency virus type 1(HIV-1):APOBEC3G can induce the conversion of cytosine to uracil in the minus-sense single-strand viral DNA, leading to G-to-A hypermutations in the subsequent plus-strand viral DNA. The resultant detrimental levels of mutations in the proviral genome, along with a deamination-independent mechanism that works prior to the proviral integration, together exert efficient antiretroviral effects in infected target cells.
• [Ref.16378963]simian foamy virus (SFV):inhibition of the replication of SFV.

PDB ID  None

Predicted Structure Download  AF-Q7YR24-F1

Modification  Phosphorylation of Thr at position 32,218.

Exhibits antiviral activity against vif-deficient: HIV-1 and simian immunodeficiency viruses (SIVs) and also against simian foamy virus (SFV).

Literature 1

Title   Species-specific exclusion of APOBEC3G from HIV-1 virions by Vif.

Pubmed ID   12859895

Author   Mariani R, Chen D, Schröfelbauer B, Navarro F, König R, Bollman B, Münk C, Nymark-McMahon H, Landau NR.

Literature 2

Title   Restriction of foamy viruses by APOBEC cytidine deaminases.

Pubmed ID   16378963

Author   Delebecque F, Suspène R, Calattini S, Casartelli N, Saïb A, Froment A, Wain-Hobson S, Gessain A, Vartanian JP, Schwartz O.