DRAVPR ID  DRAVPR0035

Name   DNA dC->dU-editing enzyme APOBEC-3H

Sequence  MALLTAETFRLQFNNKRRLRRPYYPRKALLCYQLTPQNGSTPTRGYFENKKKCHAEICFINEIKSMGLDETQCYQVTCYLTWSPCSSCAWELVDFIKAHDHLNLGIFASRLYYHWCKPQQKGLRLLCGSQVPVEVMGFPEFADCWENFVDHEKPLSFNPYKMLEELDKNSRAIKRRLERIKIPGVRAQGRYMDILCDAEV

Sequence Length  200

Source  Homo sapiens (Human)

UniProt ID Q6NTF7

Gene APOBEC3H

Target Organism  HTLV-1,HIV-1

Activity 

• [Ref.22457529]Human T-lymphotropic virus type 1(HTLV-1):APOBEC3H hapII potently decrease HTLV-1 infectivity.
• [Ref.18299330]Human immunodeficiency virus type 1 (HIV-1):APOBEC3H inhibits HIV-1 replication potently by a cytidine deamination-independent mechanism.

PDB ID  5W45  6B0B  6BBO 

Predicted Structure Download  AF-Q6NTF7-F1

Modification  No modifications on the sequence.

APOBEC3H blocked replication of both HIV-1 and SIV. Moreover, its antiretroviral activity was not countered by HIV-1 Vif.

Literature 1

Title   APOBEC3A, APOBEC3B, and APOBEC3H haplotype 2 restrict human T-lymphotropic virus type 1.

Pubmed ID   22457529

Author   Ooms M, Krikoni A, Kress AK, Simon V, Münk C.

Literature 2

Title   Human cytidine deaminase APOBEC3H restricts HIV-1 replication.

Pubmed ID   18299330

Author   Dang Y, Siew LM, Wang X, Han Y, Lampen R, Zheng YH.