DRAVPR ID  DRAVPR0036

Name   DNA dC->dU-editing enzyme APOBEC-3G

Sequence  MVEPMDPRTFVSNFNNRPILSGLNTVWLCCEVKTKDPSGPPLDAKIFQGKVYSKAKYHPEMRFLRWFHKWRQLHHDQEYKVTWYVSWSPCTRCANSVATFLAKDPKVTLTIFVARLYYFWKPDYQQALRILCQKRGGPHATMKIMNYNEFQDCWNKFVDGRGKPFKPRNNLPKHYTLLQATLGELLRHLMDPGTFTSNFNNKPWVSGQHETYLCYKVERLHNDTWVPLNQHRGFLRNQAPNIHGFPKGRHAELCFLDLIPFWKLDGQQYRVTCFTSWSPCFSCAQEMAKFISNNEHVSLCIFAARIYDDQGRYQEGLRALHRDGAKIAMMNYSEFEYCWDTFVDRQGRPFQPWDGLDEHSQALSGRLRAI

Sequence Length  370

Source  Macaca mulatta (Rhesus macaque)

UniProt ID Q7YR23

Gene APOBEC3G

Target Organism  HIV-1

Activity 

• [Ref.21835787]Human immunodeficiency virus type 1 (HIV-1):the protein expressed in CD4 T lymphocytes, are packaged into and restrict Vif-deficient HIV-1 when stably expressed in T cells, mutate proviral DNA, and are counteracted by HIV-1 Vif.

PDB ID  None

Predicted Structure Download  No predicted structure information available for the entry

Modification  Phosphorylation of Thr at position 25,211

Exhibits antiviral activity against vif-deficient: HIV-1 and simian immunodeficiency viruses (SIVs).

Literature 1

Title   Broad antiretroviral defence by human APOBEC3G through lethal editing of nascent reverse transcripts.

Pubmed ID   12859895

Author   Mangeat B, Turelli P, Caron G, Friedli M, Perrin L, Trono D.

Literature 2

Title   Human and rhesus APOBEC3D, APOBEC3F, APOBEC3G, and APOBEC3H demonstrate a conserved capacity to restrict Vif-deficient HIV-1.

Pubmed ID   21835787

Author   Hultquist JF, Lengyel JA, Refsland EW, LaRue RS, Lackey L, Brown WL, Harris RS.