DRAVPR ID  DRAVPR0052

Name   Bone marrow stromal antigen 2(Tetherin)

Sequence  MASTSYDYCRVPMEDGDKRCKLLLGIGILVLLIIVILGVPLIIFTIKANSEACRDGLRAVMECRNVTHLLQQELTEAQKGFQDVEAQAATCNHTVMALMASLDAEKAQGQKKVEELEGEITTLNHKLQDASAEVERLRRENQVLSVRIADKKYYPSSQDSSSAAAPQLLIVLLGLSALLQ

Sequence Length  180

Source  Homo sapiens (Human)

UniProt ID Q10589

Gene BST2

Target Organism  SARS-CoV,HCoV‐229E,HIV-1,LASV, MACV, ZEBOV, MARV, NiV

Activity 

• [Ref.31199522]SARS-CoV/HCoV‐229E:BST2 is capable of inhibiting SARS‐CoV and HCoV‐229E VLP release.
• [Ref.18342597]Human immunodeficiency virus 1(HIV-1):BST-2 inhibits the release of virions from cells.
• [Ref.20686043]Zaire ebolavirus (ZEBOV)/Lake Victoria marburgvirus (MARV)/Lassa virus (LASV)/Machupo virus(MACV)/paramyxoviral (NiV):BST-2 inhibits the release of a variety of VLPs, generated by the expression of arenaviral (LASV and MACV), filoviral (ZEBOV and MARV), or paramyxoviral (NiV) matrix proteins.

PDB ID  2LK9  2X7A  2XG7  3MQ7  3MQ9  4P6Z  6CM9 

Predicted Structure Download  AF-Q10589-F1

Modification  Glycosylation of Asn at position 65,92.

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Literature 1

Title   Severe acute respiratory syndrome coronavirus spike protein counteracts BST2-mediated restriction of virus-like particle release. 

Pubmed ID   31199522

Author   Wang SM, Huang KJ, Wang CT.

Literature 2

Title   The interferon-induced protein BST-2 restricts HIV-1 release and is downregulated from the cell surface by the viral Vpu protein.

Pubmed ID   18342597

Author   Van Damme N, Goff D, Katsura C, Jorgenson RL, Mitchell R, Johnson MC, Stephens EB, Guatelli J.

Literature 3

Title   Infectious Lassa virus, but not filoviruses, is restricted by BST-2/tetherin.

Pubmed ID   20686043

Author   Radoshitzky SR, Dong L, Chi X, Clester JC, Retterer C, Spurgers K, Kuhn JH, Sandwick S, Ruthel G, Kota K, Boltz D, Warren T, Kranzusch PJ, Whelan SP, Bavari S.