To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.
General Information
DRAVPR ID DRAVPR0057
Name Deoxynucleoside triphosphate triphosphohydrolase SAMHD1
Sequence
Sequence Length 626
Source Homo sapiens (Human)
UniProt ID Q9Y3Z3
Gene SAMHD1
Activity Information
Target Organism HIV-1
Activity
Structure Information
PDB ID 2E8O 4BZB 4MZ7 4QFY 4RXQ 4TNP 4TO4 6CM2 6DWD 6TXC 7LTT
Predicted Structure Download AF-Q9Y3Z3-F1
Modification ①Phosphorylation of Ser at position 18,33,93.②The N-terminal is acetylation.③Phosphorylation of Thr at position 21,25,592.
Comment
MX2 suppresses infection by all HIV-1 strains tested, has equivalent or reduced effects on divergent simian immunodeficiency viruses, and does not inhibit other retroviruses such as murine leukaemia virus.
Literature Information
Literature 1
Title Vpx relieves inhibition of HIV-1 infection of macrophages mediated by the SAMHD1 protein.
Pubmed ID 21720370
Author Hrecka K, Hao C, Gierszewska M, Swanson SK, Kesik-Brodacka M, Srivastava S, Florens L, Washburn MP, Skowronski J.
Literature 2
Title SAMHD1 is the dendritic- and myeloid-cell-specific HIV-1 restriction factor counteracted by Vpx.
Pubmed ID 21613998
Author Laguette N, Sobhian B, Casartelli N, Ringeard M, Chable-Bessia C, Ségéral E, Yatim A, Emiliani S, Schwartz O, Benkirane M.
To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.