To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.
General Information
DRAVPR ID DRAVPR0069
Name Zinc finger CCCH-type antiviral protein 1(PARP-13)
Sequence
Sequence Length 946
Source Mus musculus (Mouse)
UniProt ID Q3UPF5
Gene Zc3hav1
Activity Information
Target Organism No specific virus mentioned in the entry
Activity [Ref.21102435]PARP-13 inhibits the replication of viruses by recruiting the cellular RNA degradation machineries to degrade the viral mRNAs. Binds to a ZAP-responsive element (ZRE) present in the target viral mRNA, recruits cellular poly(A)-specific ribonuclease PARN to remove the poly(A) tail, and the 3'-5' exoribonuclease complex exosome to degrade the RNA body from the 3'-end. It also recruits the decapping complex DCP1-DCP2 through RNA helicase p72 (DDX17) to remove the cap structure of the viral mRNA to initiate its degradation from the 5'-end.
Structure Information
PDB ID 6L1W
Predicted Structure Download AF-Q3UPF5-F1
Modification ①Phosphorylation of Ser at position 257,262,265,269,273,324,350,425,553,583,680.②Phosphorylation of Thr at position 277.③Phosphorylation of Tyr at position 508.
Comment
Rat ZAP exhibits antiviral activity against diverse viruses including, in addition to alphaviruses, Moloney murine leukemia virus (MLV) and Ebola virus.
Literature Information
Literature 1
Title ZAPS is a potent stimulator of signaling mediated by the RNA helicase RIG-I during antiviral responses.
Pubmed ID 21102435
Author Hayakawa S, Shiratori S, Yamato H, Kameyama T, Kitatsuji C, Kashigi F, Goto S, Kameoka S, Fujikura D, Yamada T, Mizutani T, Kazumata M, Sato M, Tanaka J, Asaka M, Ohba Y, Miyazaki T, Imamura M, Takaoka A.
To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.