DRAVPR ID  DRAVPR0083

Name   Endoribonuclease ZC3H12A(MCPIP1)

Sequence  MSGPCGEKPVLEASPTMSLWEFEDSHSRQGTPRPGQELAAEEASALELQMKVDFFRKLGYSSTEIHSVLQKLGVQADTNTVLGELVKHGTATERERQTSPDPCPQLPLVPRGGGTPKAPNLEPPLPEEEKEGSDLRPVVIDGSNVAMSHGNKEVFSCRGILLAVNWFLERGHTDITVFVPSWRKEQPRPDVPITDQHILRELEKKKILVFTPSRRVGGKRVVCYDDRFIVKLAYESDGIVVSNDTYRDLQGERQEWKRFIEERLLMYSFVNDKFMPPDDPLGRHGPSLDNFLRKKPLTLEHRKQPCPYGRKCTYGIKCRFFHPERPSCPQRSVADELRANALLSPPRAPSKDKNGRRPSPSSQSSSLLTESEQCSLDGKKLGAQASPGSRQEGLTQTYAPSGRSLAPSGGSGSSFGPTDWLPQTLDSLPYVSQDCLDSGIGSLESQMSELWGVRGGGPGEPGPPRAPYTGYSPYGSELPATAAFSAFGRAMGAGHFSVPADYPPAPPAFPPREYWSEPYPLPPPTSVLQEPPVQSPGAGRSPWGRAGSLAKEQASVYTKLCGVFPPHLVEAVMGRFPQLLDPQQLAAEILSYKSQHPSE

Sequence Length  599

Source  Homo sapiens (Human)

UniProt ID Q5D1E8

Gene ZC3H12A 

Target Organism  HIV,JEV,DENV

Activity 

• [Ref.24191027]Human immunodeficiency virus type 1(HIV-1):MCPIP1 exhibits antiviral activity against HIV-1 in lymphocytes by decreasing the abundance of HIV-1 viral RNA species.
• [Ref.23355615]Japanese encephalitis virus (JEV)/dengue virus (DENV):MCPIP1 inhibits virus replication by binding to viral RNA.

PDB ID  3V32  3V33  3V34 

Predicted Structure Download  AF-Q5D1E8-F1

Modification  Phosphorylation of Ser at position 99,344,438,442.

MCPIP1 inhibited DENV2, encephalomyocarditis virus (EMCV), Yellow fever virus-vaccine strain 17D (YFV-17D), and the human coronavirus OC43 (HCoV-OC43), but it had a marginal effect or no effect on VSV, HSV-1, and new castle diseases virus (NDV)

Literature 1

Title   MCPIP1 restricts HIV infection and is rapidly degraded in activated CD4+ T cells.

Pubmed ID   24191027

Author   Liu S, Qiu C, Miao R, Zhou J, Lee A, Liu B, Lester SN, Fu W, Zhu L, Zhang L, Xu J, Fan D, Li K, Fu M, Wang T. 

Literature 2

Title   MCPIP1 ribonuclease exhibits broad-spectrum antiviral effects through viral RNA binding and degradation.

Pubmed ID   23355615

Author   Lin RJ, Chien HL, Lin SY, Chang BL, Yu HP, Tang WC, Lin YL.