General Information


DRAVPR ID  DRAVPR0103

Name   Transcription intermediary factor 1-beta

Sequence 

Sequence Length  835

Source  Homo sapiens (Human)

UniProt ID Q13263

Gene TRIM28



Activity Information


Target Organism  MLV

Activity 

  • [Ref.18248090]murine leukemia virus (MLV):TRIM28 restricts MLV in cells of germline origin by inhibiting LTR-driven transcription.



Structure Information


PDB ID  1FP0  2RO1  6H3A  6QU1 

Predicted Structure Download  AF-Q13263-F1

';

Modification  ①The Lys at position 266,304,340,377,770,779 indicates N6-acetyllysine.②Phosphorylation of Tyr at position 755.③Phosphorylation of Thr at position 498,541.④Phosphorylation of Ser at position 19,26,50,138,417,437,439,453,471,473,479,489,501,594,683,689,697,752,757,784,824.⑤The N-terminal is acetylation.



Comment


TRIM28 was shown to repress transcription from a retroviral promoter by binding to proviral DNA.



Literature Information


Literature 1

Title   TRIM E3 ligases interfere with early and late stages of the retroviral life cycle. 

Pubmed ID   18248090

Author   Uchil PD, Quinlan BD, Chan WT, Luna JM, Mothes W.

Literature 2

Title   The interferon response inhibits HIV particle production by induction of TRIM22.

Pubmed ID   18389079

Author   Barr SD, Smiley JR, Bushman FD.