General Information
DRAVPR ID DRAVPR0103
Name Transcription intermediary factor 1-beta
Sequence
Sequence Length 835
Source Homo sapiens (Human)
UniProt ID Q13263
Gene TRIM28
Activity Information
Target Organism MLV
Activity
Structure Information
Predicted Structure Download AF-Q13263-F1
Modification ①The Lys at position 266,304,340,377,770,779 indicates N6-acetyllysine.②Phosphorylation of Tyr at position 755.③Phosphorylation of Thr at position 498,541.④Phosphorylation of Ser at position 19,26,50,138,417,437,439,453,471,473,479,489,501,594,683,689,697,752,757,784,824.⑤The N-terminal is acetylation.
Comment
TRIM28 was shown to repress transcription from a retroviral promoter by binding to proviral DNA.
Literature Information
Literature 1
Title TRIM E3 ligases interfere with early and late stages of the retroviral life cycle.
Pubmed ID 18248090
Author Uchil PD, Quinlan BD, Chan WT, Luna JM, Mothes W.
Literature 2
Title The interferon response inhibits HIV particle production by induction of TRIM22.
Pubmed ID 18389079
Author Barr SD, Smiley JR, Bushman FD.