To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.
General Information
DRAVPR ID DRAVPR0103
Name Transcription intermediary factor 1-beta
Sequence
Sequence Length 835
Source Homo sapiens (Human)
UniProt ID Q13263
Gene TRIM28
Activity Information
Target Organism MLV
Activity
Structure Information
Predicted Structure Download AF-Q13263-F1
Modification ①The Lys at position 266,304,340,377,770,779 indicates N6-acetyllysine.②Phosphorylation of Tyr at position 755.③Phosphorylation of Thr at position 498,541.④Phosphorylation of Ser at position 19,26,50,138,417,437,439,453,471,473,479,489,501,594,683,689,697,752,757,784,824.⑤The N-terminal is acetylation.
Comment
TRIM28 was shown to repress transcription from a retroviral promoter by binding to proviral DNA.
Literature Information
Literature 1
Title TRIM E3 ligases interfere with early and late stages of the retroviral life cycle.
Pubmed ID 18248090
Author Uchil PD, Quinlan BD, Chan WT, Luna JM, Mothes W.
Literature 2
Title The interferon response inhibits HIV particle production by induction of TRIM22.
Pubmed ID 18389079
Author Barr SD, Smiley JR, Bushman FD.
To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.