To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.
General Information
DRAVPR ID DRAVPR0113
Name Tripartite motif-containing protein 14
Sequence
Sequence Length 440
Source Mus musculus (Mouse)
UniProt ID Q8BVW3
Gene Trim14
Activity Information
Target Organism HSV-1
Activity
Structure Information
PDB ID None
Predicted Structure Download AF-Q8BVW3-F1
Modification No modifications on the sequence.
Comment
TRIM14 enhances RIG-I-mediated activation of type I IFN responses against RNA viruses. TRIM14 deficiency resulted in impaired activation of type I IFN responses by causing fewer IFNs and ISGs to be produced upon VSV infection in murine primary cells.
Literature Information
Literature 1
Title TRIM14 Inhibits cGAS Degradation Mediated by Selective Autophagy Receptor p62 to Promote Innate Immune Responses
Pubmed ID 27666593
Author Chen M, Meng Q, Qin Y, Liang P, Tan P, He L, Zhou Y, Chen Y, Huang J, Wang RF, Cui J.
To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.