DRAVPR ID  DRAVPR0139

Name   Griffithsin(GRFT)

Sequence  SLTHRKFGGSGGSPFSGLSSIAVRSGSYLDXIIIDGVHHGGSGGNLSPTFTFGSGEYISNMTIRSGDYIDNISFETNMGRRFGPYGGSGGSANTLSNVKVIQINGSAGDYLDSLDIYYEQY

Sequence Length  121

Source  Griffithsia sp. (strain Q66D336) (Red alga)

UniProt ID P84801

Gene N/A

Target Organism  HIV

Activity 

• [Ref.20032190]Human immunodeficiency virus type 1(HIV-1) RF:The potent cytoprotective and anti-replicative activities of GRFT in CEM-SS cells(EC50= 0.043 nM);
• Human immunodeficiency virus type 1(HIV-1) ROJO:The potent cytoprotective and anti-replicative activities of GRFT in CEM-SS cells(EC50= 0.63 nM);
• Human immunodeficiency virus type 1(HIV-1) ADA:The potent cytoprotective and anti-replicative activities of GRFT in CEM-SS cells(EC50= 0.50 nM);
• Human immunodeficiency virus type 1(HIV-1) BaL:The potent cytoprotective and anti-replicative activities of GRFT in CEM-SS cells(EC50= 0.098 nM).

PDB ID  2GTY  2GUD  2NUO  3LL2 

Predicted Structure Download  No predicted structure information available for the entry

Modification  No modifications on the sequence.

GRFT blocked CD4-dependent glycoprotein (gp) 120 binding to receptor-expressing cells and bound to viral coat glycoproteins (gp120, gp41, and gp160) in a glycosylation-dependent manner.

Literature 1

Title   Broad-spectrum in vitro activity and in vivo efficacy of the antiviral protein griffithsin against emerging viruses of the family Coronaviridae

Pubmed ID   20032190

Author   Mori T, O'Keefe BR, Sowder RC 2nd, Bringans S, Gardella R, Berg S, Cochran P, Turpin JA, Buckheit RW Jr, McMahon JB, Boyd MR.