DRAVPR ID  DRAVPR0165

Name   SLPI

Sequence  SGKSFKAGVCPPKKSAQCLRYKKPECQSDWQCPGKKRCCPDTCGIKCLDPVDTPNPTRRKPGKCPVTYGQCLMLNPPNFCEMDGQCKRDLKCCMGMCGKSCVSPVKA

Sequence Length  107

Source  tears, saliva, airway, gastrointestines, genital tracts, Homo sapiens

UniProt ID P03973

Gene ELANE

Target Organism  HIV-1

Activity 

• [Ref:15731023]HIV-1:SLPI was found to be the most potent anti-HIV-1 factor among several innate inhibitory molecules, namely, virus-specific antibodies, mucins, and thrombospondins, identified and purified from saliva.Moderate activity is also exerted against HIV-2 strains, but only when the concentration of SLPI exceeds the norm.The mechanism by which SLPI inhibits HIV-1 infection is still elusive, but it appears to involve the host cell target rather than binding to the virus.Evidence suggests that SLPI blocks HIV-1 internalization in a dose-dependent manner rather than binding to CD4.McNeely et al. found that SLPI most likely inhibits a step of viral infection that occurs after virus binding but before reverse transcription. They also succeeded in preventing HIV infection of macrophages after pretreatment with SLPI.

PDB ID  2Z7F, 4DOQ 

Predicted Structure Download  No predicted structure information available for the entry

Modification  N-terminal transglutaminase domain substrate and a C-terminal four-disulfide core

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Literature 1

Title   Anti-inflammatory and antimicrobial roles of secretory leukocyte protease inhibitor

Pubmed ID   15731023

Author   Doumas, S., Kolokotronis, A., & Stefanopoulos, P. (2005).