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DRAVP ID DRAVPa1438
Peptide Name Sequence 1 from Patent US 20050130884
Sequence RRKKAAVALLPAVLLALLAP
Sequence Length 20
Source Synthetic construct
Target Organism HSV
Patent Type Patent Application
Publication Date 2005-06-16
Patent No US 2005/0130884 A1
Family Info WO 2001/057072 A2, CA 2399676 A1, AU 2001/036700 A, WO 2001/057072 A3, EP 1272510 A2, JP 2003522185 A, US 2005/0130884 A1, AU 784264 B2, EP 1272510 B1, AT 374208 T, DE 60130641 D1, ES 2293977 T3, US 7
Patent Title Pharmacologically active antiviral peptides and methods of their use
Comment The peptide shows antiviral activity against a wide range of enveloped and non-enveloped viruses. Examples of such enveloped viruses include, but are not limited to, human immunodeficiency virus (HIV), vesiculovirus (VSV), herpes simplex viruses (HSV-1 and HSV-2), and other herpes viruses, for example, varicella-zoster virus (VZV), EBV, equine herpes virus (EHV), and human cytomegalovirus (HCMV). Examples of non-enveloped viruses include, but are not limited to, human papilloma virus (HPV) and adenoviruses.The peptide shows antiviral activity against HSV by blocking virus entry(IC50=15-26 μM).
Abstract This invention relates to peptides having antiviral properties. The antiviral peptides comprise membrane transiting peptides, and active fragments and derivatives of such peptides. The antiviral peptides exhibit activity against a broad spectrum of viruses, including enveloped and nonenveloped viruses, and are used in pharmaceutical compositions to prevent and/or treat viral infections.
Other Link DRAVPe01185
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